Name: Human UBA5 Recombinant Protein (His Tag)
Synonyms: Ubiquitin-like modifier-activating enzyme 5;ThiFP1;UFM1-activating enzyme;Ubiquitin-activating enzyme E1 domain-containing protein 1;UBE1DC1;UBA5
Expression host: E.coli
Sequence: Met 1-Met404
Accesstion: Q9GZZ9
Species: Human
Mol_Mass: 47.0 kDa
AP_Mol_Mass: 14&40-60 kDa
Tag: N-His
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50mM NaCl, 1mM DTT, 10% Glycerol, pH8.0.
Reconstitution: Not Applicable
Background: UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. UBA5 is located primarily in cytoplasm, while it generally localizes to the nucleus in presence of SUMO2.
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