Name: Human Tryptase β-2/TPSB2 Recombinant Protein (His Tag)
Synonyms: Tryptase Beta-2;Tryptase-2;Tryptase II;TPSB2;TPS2
Expression host: HEK293 Cells
Sequence: Ala19-Pro275
Accesstion: AAH29356.1
Species: Human
Mol_Mass: 29.6 kDa
AP_Mol_Mass: 30-35 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution: Not Applicable
Background: Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, β-Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, β-Tryptases are released and participate in provoking inflammatory conditions . β-Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders.
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