Name: Human TRAIL R3/TNFRSF10C Recombinant Protein (His Tag)
Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 10C;Antagonist Decoy Receptor for TRAIL/Apo-2L;Decoy TRAIL Receptor Without Death Domain;Decoy Receptor 1;DcR1;Lymphocyte Inhibitor of TRAIL;TNF-Related Apoptosis-Inducing Ligand Receptor 3;TRAIL Receptor 3;TRAIL-R3;TRAIL Receptor Without an Intracellular Domain;CD263;TNFRSF10C;DCR1;LIT;TRAILR3;TRID
Expression host: HEK293 Cells
Sequence: Ala26-Ala221
Accesstion: O14798
Species: Human
Mol_Mass: 21.8 kDa
AP_Mol_Mass: 38-58 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed man
Reconstitution: Please refer to the printed manual for detailed information.
Background: Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains; lacks the intracellular signaling domain. As a result; binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
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