Name: Human TPP1/CLN2 Recombinant Protein (His Tag)

Synonyms: Tripeptidyl-Peptidase 1;TPP-1;Cell Growth-Inhibiting Gene 1 Protein;Lysosomal Pepstatin-Insensitive Protease;LPIC;Tripeptidyl Aminopeptidase;TPP1;CLN2;GIG1;LPIC;SCAR7;TPP-1

Expression host: HEK293 Cells

Sequence: Ser20-Pro563

Accesstion: AAH14863.1

Species: Human

Mol_Mass: 60.4 kDa

AP_Mol_Mass: 74 kDa

Tag: C-His

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM CaCl2, 10% Glycerol, pH 7.5.

Reconstitution: Not Applicable

Background: Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2).

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