Name: Human TIM-3/HAVCR2 Recombinant Protein (His Tag)
Synonyms: Hepatitis A Virus Cellular Receptor 2;HAVcr-2;T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3;TIMD-3;T-Cell Membrane Protein 3;TIM-3;HAVCR2;TIM3;TIMD3
Expression host: HEK293 Cells
Sequence: Ser22-Arg200
Accesstion: AAL65157.1
Species: Human
Mol_Mass: 20.9 kDa
AP_Mol_Mass: 37 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed man
Reconstitution: Please refer to the printed manual for detailed information.
Background: T-Cell Membrane Protein 3 (TIM3) is a single-pass type I membrane protein that belongs to the TIM family of immunoglobulin superfamily. TIM3 includes a signal sequence (aa 1-21); an extracellular region (aa 22-202) with one Ig-like V-type domain; a transmembrane segment (aa 203-223); and a cytoplasmic domain (aa 224 – 301). TIM3 regulates macrophage activation; inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and as a receptor for LGALS9.
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