Name: Human Tetherin/BST2 Recombinant Protein (His Tag)
Synonyms: Bone Marrow Stromal Antigen 2;BST-2;HM1.24 Antigen;Tetherin;CD317;BST2
Expression host: HEK293 Cells
Sequence: Asn49-Ser161
Accesstion: Q10589
Species: Human
Mol_Mass: 13.7 kDa
AP_Mol_Mass: 23 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed man
Reconstitution: Please refer to the printed manual for detailed information.
Background: Bone Marrow Stromal Antigen 2 (BST2) is a single-pass type II membrane protein that belongs to the tetherin family. BST2 is predominantly expressed in the liver; lung; heart and placenta. BST2 is involved in the sorting of secreted proteins. BST2 is a human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells. BST2 is initially discovered as an inhibitor to HIV-1 infection in the absence of Vpu; it has also been shown to inhibit the release of other viruses such as retroviruses; filoviruses; arenaviruses; and herpes viruses. BST2 may play a role in B-cell activation in rheumatoid arthritis.
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