Name: Human SGSH Recombinant Protein (His Tag)
Synonyms: N-Sulphoglucosamine Sulphohydrolase;Sulfoglucosamine Sulfamidase;Sulphamidase;SGSH;HSS
Expression host: HEK293 Cells
Sequence: Arg21-Leu502
Accesstion: P51688
Species: Human
Mol_Mass: 55.7 kDa
AP_Mol_Mass: 63 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM CaCl2, 10% Glycerol, pH 7.5.
Reconstitution: Not Applicable
Background: N-Sulphoglucosamine Sulphohydrolase (SGSH) is an important member of the sulfatase family which is involved in the degradation of heparin sulfate. SGSH binds one calcium ion per subunit as a cofactor. SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. SGSH deficiency is result in mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations.
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