Name: Human SENP7 Recombinant Protein
Synonyms: Sentrin-Specific Protease 7;SUMO-1-Specific Protease 2;Sentrin/SUMO-Specific Protease SENP7;SENP7;KIAA1707;SSP2;SUSP2
Expression host: E.coli
Sequence: Met695-Ala864
Accesstion: Q9BQF6
Species: Human
Mol_Mass: 19.8 kDa
AP_Mol_Mass: 22 kDa
Tag: None
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 5% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Background: Sentrin-Specific Protease 7 (SENP7) acts as a SUMO-2/3-specific protease. SENP7 is likely to regulate the metabolism of poly-SUMO-2/3 rather than SUMO-1 conjugation in vivo. SENP7 has a restricted substrate specificity, and displaying paralogue-specific isopeptidase activity. The C-terminal catalytic domain of SENP7 depolymerized poly-SUMO-2 chains but does not have activity against poly-SUMO-1 chains. SENP7 also had isopeptidase activity against di-SUMO-2- and SUMO-2-modified RanGAP1 (Ran GTPase-activating protein 1) but had limited activity against SUMO-1-modified RanGAP1.
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