Name: Human SELENOI/EPT1 Recombinant Protein (GST Tag)
Synonyms: Ethanolaminephosphotransferase 1;hEPT1;Selenoprotein I;SelI;EPT1;KIAA1724;SELI
Expression host: E.coli
Sequence: Met 1-Pro50
Accesstion: Q9C0D9
Species: Human
Mol_Mass: 32.6 kDa
AP_Mol_Mass: 29 kDa
Tag: N-GST
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0.
Reconstitution: Not Applicable
Background: Ethanolaminephosphotransferase 1 (EPT1) is an enzyme that belongs to the CDP-Alcohol Phosphatidyltransferase Class-I Family. EPT1 is a Selenoprotein, which contains a Selenocysteine (Sec) residue at its active site. The Selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3′ UTR of Selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. EPT1 catalyzes Phosphatidylethanolamine biosynthesis from CDP-Ethanolamine. It plays a central role in the formation and maintenance of vesicular membranes. EPT1 is involved in the formation of Phosphatidylethanolamine via the ‘Kennedy’ pathway.
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