Name: Human S100B Recombinant Protein (His Tag)
Synonyms: Protein S100-B;S-100 protein beta chain;S-100 protein subunit beta;S100 calcium-binding protein B;S100b;S100 beta;S100 calcium binding protein B;NEF;S100;S100-B;S100beta
Expression host: E.coli
Sequence: Met 1-Glu92
Accesstion: P04271
Species: Human
Mol_Mass: 12.2 kDa
AP_Mol_Mass: 12 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed man
Reconstitution: Please refer to the printed manual for detailed information.
Background: S100-B; is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment; differentiation; and brain construction. S100-B has neuroprotective effects; but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage; which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS; and the astrocytes are the major cells producing S100-B protein in gray matter; as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop; enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition; S100-B; which is also present in human melanocytes; is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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