Name: Human ROR2 Recombinant Protein (His Tag)
Synonyms: Tyrosine-protein kinase transmembrane receptor ROR2;Neurotrophic tyrosine kinase;receptor-related 2;ROR2;NTRKR2
Expression host: HEK293 Cells
Sequence: Glu34-Gly403
Accesstion: Q01974
Species: Human
Mol_Mass: 42.2 kDa
AP_Mol_Mass: 50-60 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Receptor Tyrosine Kinaselike Orphan Receptor 2(ROR2) belongs to the protein kinase superfamily, Tyr protein kinase family and ROR subfamily. It is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the development of the central nervous system. ROR2 promotes osteogenesis, binds YWHAB and Interacts with WTIP. ROR2 is broadly expressed during embryonic development and can be found in cells of all three germ layers as well as in most organ tissues. Activation of ROR2 signaling promotes cellular proliferation, differentiation, cellpolarization, and migration. ROR2 has also been shown to have very little tyrosine kinase activity in vitro and may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
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