Name: Human Rock-2 Recombinant Protein (His tag)
Synonyms: Rho kinase 2;Rho-associated;Rho-associated protein kinase 2;ROCK 2;Rock II;Rock2;ROCK2;Rock2m;ROK alpha;ROKalpha
Expression host: E.coli
Sequence: Leu 904-Gly 1140
Accesstion: O75116
Species: Human
Mol_Mass: 26.0 kDa
AP_Mol_Mass: 35 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from sterile PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: ROCK2/II (Rho-associated protein kinase 2; also Rho-kinase alpha ) is a member of the AGC serine/threonine protein kinase family. ROCK2 is a downstream target of activated RhoA. Its activation results in myosin phosphorylation with subsequent muscle contraction. Human ROCK2 is 1388 amino acids (aa) in length, and appears to be present as a dimer. It contains a protein kinase domain (aa 92?354), a coiled-coil region (aa 429?1131) and a zinc-finger region (aa 1260?1315). Two isoforms show an alternate start site at M686, and a three aa substitution for the N-terminal 444 amino acids.
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