Name: Human RIDA/HRSP12 Recombinant Protein (His Tag)
Synonyms: Ribonuclease UK114;14.5 kDa Translational Inhibitor Protein;p14.5;Heat-Responsive Protein 12;UK114 Antigen Homolog;HRSP12;PSP
Expression host: E.coli
Sequence: Met 1-Leu137
Accesstion: P52758
Species: Human
Mol_Mass: 16.7 kDa
AP_Mol_Mass: 16 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 10% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.
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