Name: Human Ribonuclease 3/RNASE3 Recombinant Protein (His Tag)
Synonyms: Eosinophil Cationic Protein;ECP;Ribonuclease 3;RNase 3;RNASE3;ECP;RNS3
Expression host: HEK293 Cells
Sequence: Arg28-Ile160
Accesstion: AAH96060.1
Species: Human
Mol_Mass: 16.6 kDa
AP_Mol_Mass: 25-35 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mMDTT, 10% Glycerol, pH 7.5.
Reconstitution: Not Applicable
Background: Ribonuclease 3 (RNASE3) is a basic protein that is localized to the eosinophil primary matrix and belongs to the pancreatic ribonuclease family. RNASE3 is released during degranulation of eosinophils. RNASE3 possesses a wide variety of biological activities. RNASE3 interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). RNASE3 exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. It promotes E. coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
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