Name: Human RANK/TNFRSF11A Recombinant Protein (His Tag)
Synonyms: CD265;ODFR;TNFRSF11A;TRANCE R;CD265;CD265 antigen;FEO;ODFROSTS;OFE;OPTB7;PDB2;RANK1;Receptor activator of NF-KB;receptor activator of nuclear factor-kappa B;TRANCER;tumor necrosis factor receptor superfamily member 11A
Expression host: HEK293 Cells
Sequence: Ile30-Pro212
Accesstion: Q9Y6Q6
Species: Human
Mol_Mass: 21.1 kDa
AP_Mol_Mass: 25-30 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.
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