Name: Human PYM1/WIBG Recombinant Protein (His Tag)
Synonyms: Partner of Y14 and Mago;Protein Wibg Homolog;WIBG;PYM
Expression host: E.coli
Sequence: Met 1-Leu204
Accesstion: Q9BRP8
Species: Human
Mol_Mass: 23.7 kDa
AP_Mol_Mass: 30 kDa
Tag: C-His
Purity: > 80 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 10% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Partner of Y14 and Mago (WIBG) is a key regulator of the Exon Junction Complex (EJC). EJC is a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs, is a positional landmarker for the intron exon structure of genes, and directs post-transcriptional processes in the cytoplasm, for instance mRNA export, nonsense-mediated mRNA decay or translation. WIBG is a cytoplasmic RNA-binding protein, it can be excluded from nucleus by Crm1. WIBG as a cooperateing partner of Mago-14, relates with Mago-14 by its N-terminal domain.
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