Name: Human PTPN6/SH-PTP1 Recombinant Protein (His Tag)
Synonyms: Tyrosine-Protein Phosphatase Non-Receptor Type 6;Hematopoietic Cell Protein-Tyrosine Phosphatase;Protein-Tyrosine Phosphatase 1C;PTP-1C;Protein-Tyrosine Phosphatase SHP-1;SH-PTP1;PTPN6;HCP;PTP1C
Expression host: E.coli
Sequence: Lys243-Ile541
Accesstion: AAH02523.1
Species: Human
Mol_Mass: 35.4 kDa
AP_Mol_Mass: 34 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 2mM β-ME, 1mM EDTA, 1mM DTT, 20% Glycerol, pH 7.5.
Reconstitution: Not Applicable
Background: Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine Phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein Phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own Phosphatase activity against interacting substrates. In addition, PTP1C also modulates signaling by tyrosine phosphorylated cell surface receptors.
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