Name: Human PSMA Recombinant Protein (His Tag)
Synonyms: Glutamate carboxypeptidase 2;FGCP;GCPII;mGCP;NAALADase I;PSMA;Cell growth-inhibiting gene 27 protein;Folate hydrolase 1;FOLH1;GCP2;FGCP;GCPII;Mgcp;NAALADase I;FOLH;mGCP;NAALAD1;NAALAdase;PSM;PSMA
Expression host: HEK293 Cells
Sequence: Lys44-Ala750
Accesstion: Q04609
Species: Human
Mol_Mass: 80.6 kDa
AP_Mol_Mass: 90-120 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 5% Trehalose, pH 5.5.
Reconstitution: Not Applicable
Background: Glutamate carboxypeptidase 2, also known as FOLH1, PSMA, belongs to the M28B subfamily and the peptidase M28 family. It is highly expressed in prostate epithelium and can be detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. PSMA involves in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, PSMA cleaves Gly-Pro-AMC. PSMA is stable at pH greater than 6.5.
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