Name: Human Recombinant Proteinase 3/PRTN3 Recombinant Protein (His Tag)
Synonyms: Myeloblastin;AGP7;C-ANCA Antigen;Leukocyte Proteinase 3;PR-3;PR3;Neutrophil Proteinase 4;NP-4;P29;Wegener Autoantigen;PRTN3;MBN
Expression host: HEK293 Cells
Sequence: Ala26-Arg249
Accesstion: P24158
Species: Human
Mol_Mass: 25.6 kDa
AP_Mol_Mass: 34 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 10mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener’s granulomatosis.
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