Name: Human PRKG1 Recombinant Protein (His Tag)
Synonyms: cGMP-Dependent Protein Kinase 1;cGK 1;cGK1;cGMP-Dependent Protein Kinase I;cGKI;PRKG1;PRKG1B;PRKGR1A;PRKGR1B
Expression host: HEK293 Cells
Sequence: Gly2-Pro686
Accesstion: Q13976-2
Species: Human
Mol_Mass: 78.8 kDa
AP_Mol_Mass: 75 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 6% Sucrose, 4% Mannitol, 0.05% Tween 80, pH8.0.
Reconstitution: Not Applicable
Background: cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm, and nociception.
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