Name: Human PRCP Recombinant Protein (His Tag)
Synonyms: Lysosomal Pro-X Carboxypeptidase;Angiotensinase C;Lysosomal Carboxypeptidase C;Proline Carboxypeptidase;ProlylCarboxypeptidase;PRCP;PRCP;PCP
Expression host: HEK293 Cells
Sequence: Leu22-His496
Accesstion: P42785
Species: Human
Mol_Mass: 54.5 kDa
AP_Mol_Mass: 60-90 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM NaAc-HAc, 150mM NaCl, 10% Glycerol, pH4.5.
Reconstitution: Not Applicable
Background: Lysosomal Pro-X Carboxypeptidase (PRCP) belongs to the peptidase S28 family. PRCP is detected in many tissues, with highest levels observed in placenta, lung, and liver. It is also present in the heart, brain, pancreas, and kidney. PRCP exists as a homodimer. PRCP cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. PRCP has been shown to be an activator of the cell matrix-associated prekallikrein.
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