Name: Human PPP1R14A Recombinant Protein (His Tag)
Synonyms: Protein Phosphatase 1 Regulatory Subunit 14A;17 kDa PKC-Potentiated Inhibitory Protein of PP1;Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa;CPI-17;PPP1R14A;CPI17;PPP1INL
Expression host: E.coli
Sequence: Met 1-Pro147
Accesstion: Q96A00
Species: Human
Mol_Mass: 17.8 kDa
AP_Mol_Mass: 23-26 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 0.2mM EDTA, 1mM DTT, 10% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime; PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin Phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated; PPP1R14A has over 1000-fold higher inhibitory activity; creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition; inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
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