Name: Human PPM1A Recombinant Protein (His tag)
Synonyms: Protein Phosphatase 1A;Protein Phosphatase 2C Isoform Alpha;PP2C-Alpha;Protein Phosphatase IA;PPM1A;PPPM1A;PP2C-ALPHA;PP2CA;PP2Calpha
Expression host: E.coli
Sequence: Gly2-Trp382
Accesstion: P35813
Species: Human
Mol_Mass: 41.8 kDa
AP_Mol_Mass: 45 kDa
Tag: N-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from sterile PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein Phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also; it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3; resulting in their dissociation from SMAD4; nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition; PPM1A can dephosphorylate cyclin-dependent kinases; and thus may be involved in cell cycle control.
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