Name: Human PI3/Elafin Recombinant Protein (His Tag)
Synonyms: Elafin;Elastase-Specific Inhibitor;ESI;Peptidase Inhibitor 3;PI-3;Protease inhibitor WAP3;Skin-Derived Antileukoproteinase;SKALP;WAP Four-Disulfide Core Domain Protein 14;PI3;WAP3;WFDC14
Expression host: HEK293 Cells
Sequence: Ala23-Gln117
Accesstion: P19957
Species: Human
Mol_Mass: 11.0 kDa
AP_Mol_Mass: 13-18 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5.
Reconstitution: Not Applicable
Background: Elafin is a secreted protein. Elafin consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize Elafin covalently to specific sites on extracellular matrix proteins. It is shown that Elafin can be used as a biomarker for graft versus host disease of the skin. Elafin is expressed in the skin during wound healing through activation of the epidermal growth factor receptor. Elafin may prevent elastase-mediated tissue proteolysis.
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