Name: Human PGD2 Synthase/PTGDS Recombinant Protein (His Tag)
Synonyms: Prostaglandin D Synthase;Prostaglandin-H2 D-Isomerase;Beta-Trace Protein;Cerebrin-28;Glutathione-Independent PGD Synthase;Lipocalin-Type Prostaglandin-D Synthase;Prostaglandin-D2 Synthase;PGD2 Synthase;PGDS;PGDS2;PTGDS;PDS
Expression host: HEK293 Cells
Sequence: Ala23-Gln190
Accesstion: P41222
Species: Human
Mol_Mass: 19.7 kDa
AP_Mol_Mass: 20-27 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Reconstitution: Not Applicable
Background: Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.
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