Name: Human PDCD4 Recombinant Protein (His Tag)
Synonyms: Death up-regulated gene protein;Dug;H731;Ma3;MGC33046;MGC33047;Neoplastic transformation inhibitor;Neoplastic transformation inhibitor protein;Nuclear antigen H731;Nuclear antigen H731 like;Nuclear antigen H731 like protein;Nuclear antigen H731-like;PDCD 4;PdCD4;PDCD4;Programmed cell death 4;programmed cell death 4 (neoplastic transformation inhibitor);Programmed cell death protein 4;Protein 197/15a;Protein MA-3;Tis;Topoisomerase-inhibitor suppressed protein
Expression host: E.coli
Sequence: Met1-Asn325
Accesstion: Q53EL6
Species: Human
Mol_Mass: 36.9 kDa
AP_Mol_Mass: 41-43 kDa
Tag: N-His
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from sterile PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation.
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