Name: Human PD-L2/CD273 Recombinant Protein (mFc Tag)
Synonyms: Programmed Cell Death 1 Ligand 2;PD-1 Ligand 2;PD-L2;PDCD1 Ligand 2;Programmed Death Ligand 2;Butyrophilin B7-DC;B7-DC;CD273;PDCD1LG2;B7DC;CD273;PDCD1L2;PDL2
Expression host: HEK293 Cells
Sequence: Leu20-Pro219
Accesstion: Q9BQ51
Species: Human
Mol_Mass: 49.2 kDa
AP_Mol_Mass: 60-90 kDa
Tag: C-mFc
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Programmed Cell Death 1 Ligand 2 (PDCD1LG2) is a member of the BTN/MOG family. PDCD1LG2 contains one Ig-like C2-type domain and one Ig-like V-type domain. PDCD1LG2 is highly expressed in the heart; placenta; pancreas; lung and liver; it is weakly expressed in the spleen; lymph nodes; and thymus. PDCD1LG2 is involved in the costimulatory signal; essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PDCD1LG2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
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