Name: Human PADI4 Recombinant Protein (His Tag)

Synonyms: Protein-Arginine Deiminase Type-4;HL-60 PAD;Peptidylarginine Deiminase IV;Protein-arginine Deiminase type IV;PADI4;PADI5;PDI5

Expression host: E.coli

Sequence: Met 1-Pro663

Accesstion: AAH25718.1

Species: Human

Mol_Mass: 76.2 kDa

AP_Mol_Mass: 78 kDa

Tag: N-His

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin:

Storage: Store at

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at

Formulation: Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 500mM NaCl, pH 7.5.

Reconstitution: Not Applicable

Background: Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.

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