Name: Human OSMR/IL31RB Recombinant Protein (aa 28-739, His Tag)
Synonyms: Oncostatin-M-Specific Receptor Subunit Beta;Interleukin-31 Receptor Subunit Beta;IL-31 Receptor Subunit Beta;IL-31R Subunit Beta;IL-31R-Beta;IL-31RB;OSMR;OSMRB;PLCA1
Expression host: HEK293 Cells
Sequence: Glu28-Ser739
Accesstion: Q99650
Species: Human
Mol_Mass: 82.0 kDa
AP_Mol_Mass: 132 kDa
Tag: C-His
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed man
Reconstitution: Please refer to the printed manual for detailed information.
Background: Oncostatin-M-Specific Receptor Subunit β (OSMRβ) is a 150 – 180 kDa member of the IL-6 receptor family. OSMRβ associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRβ associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRβ cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.
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