Name: Human OLR1/LOX-1 Recombinant Protein (His tag)
Synonyms: Oxidized Low-Density Lipoprotein Receptor 1;Ox-LDL Receptor 1;C-Type Lectin Domain Family 8 Member A;Lectin-Like Oxidized LDL Receptor 1;LOX-1;Lectin-Like oxLDL Receptor 1;hLOX-1;Lectin-Type Oxidized LDL Receptor 1;OLR1;CLEC8A;LOX1;LOXIN;SCARE1;
Expression host: HEK293 Cells
Sequence: Ser61-Gln273
Accesstion: P78380
Species: Human
Mol_Mass: 23.3 kDa
AP_Mol_Mass: 32 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from sterile PBS, pH 7.4.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted; single-pass type II membrane protein which belongs to the C-type lectin superfamily. Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta; lung; liver; brain; aortic intima; bone marrow; spinal cord and substantia nigra. The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF; IFNG and IL6 by pathological conditions; such as hyperlipidemia; hypertension and diabetes mellitus. Ox-LDL Receptor 1 mediates the recognition; internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells. Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release; monocyte adhesion and apoptosis. Ox-LDL Receptor 1 also binds to oxLDL; which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells; thereby participating in cell-mediated antigen cross-presentation. It also participates in inflammatory process; by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
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