Name: Human OBFC1/STN1 Recombinant Protein (His Tag)
Synonyms: CST Complex Subunit STN1;Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 1;Suppressor of Cdc Thirteen Homolog;OBFC1;STN1
Expression host: E.coli
Sequence: Met 1-Phe368
Accesstion: AAH17400.1
Species: Human
Mol_Mass: 44.3 kDa
AP_Mol_Mass: 44 kDa
Tag: N-His
Purity: > 80 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 5% Trehalose, pH 8.0.Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information i
Reconstitution: Please refer to the printed manual for detailed information.
Background: CST Complex Subunit STN1 (OBFC1) is a 368 amino acid protein that contains one OB DNA-binding domain. It is a member of the STN1 family. OBFC1 is component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
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