Name: Human N-Glycosylase/OGG1 Recombinant Protein
Synonyms: N-Glycosylase/DNA Lyase;8-Oxoguanine DNA Glycosylase;DNA-(Apurinic or Apyrimidinic Site) Lyase;AP Lyase;OGG1;MMH;MUTM;OGH1
Expression host: E.coli
Sequence: Met 1-Gly345
Accesstion: AAH00657.1
Species: Human
Mol_Mass: 38.8 kDa
AP_Mol_Mass: 38 kDa
Tag: None
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.5.
Reconstitution: Not Applicable
Background: Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.
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