Name: Human MTHFS Recombinant Protein (His Tag)
Synonyms: 5-formyltetrahydrofolate cyclo-ligase;5,10-methenyl-tetrahydrofolate synthetase;MTHFS;Methenyl-THF synthetase
Expression host: E.coli
Sequence: Met 1-Ala203
Accesstion: P49914
Species: Human
Mol_Mass: 24.3 kDa
AP_Mol_Mass: 28 kDa
Tag: C-His
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM Nacl, 1mM DTT, 50% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: 5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion.
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