Name: Human LAG3/CD223 Recombinant Protein (Fc Tag)
Synonyms: Lymphocyte activation gene 3 protein;LAG3;LAG-3;Protein FDC;CD223;LAG-3
Expression host: HEK293 Cells
Sequence: Leu23-Leu450
Accesstion: P18627
Species: Human
Mol_Mass: 73.3 kDa
AP_Mol_Mass: 70-90 kDa
Tag: C-Fc
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin:
Storage: Store at
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at
Formulation: Supplied as a 0.2 μm filtered solution of 20mM NaH2PO4, 150mM NaCl, 0.1M Arginine, 0.1M Glu, 10% Glycerol, 0.01% Tween20, 5% Trehalose, pH 7.4.
Reconstitution: Not Applicable
Background: Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
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