enes at this time have already been linked with all the pathogen manipulation of your host, as the use of sugars like fructose and amino acids are important sources to get a prosperous colonization, as described in P. infestans (Botero et al., 2018). This also indicates that the interaction amongst S. betaceum and P. betacei is compatible, because the induction of expression of those genes correlates with a a lot more susceptible interaction (Duan et al., 2020). On the STAT5 Storage & Stability functional category for secondary metabolite production, at 24 hpi there was an overall enrichment, in specific of biosynthesis of terpenoid, phenylpropanoid, and lignin, typically active defense pathways against biotic and abiotic pressure (Paolinelli-Alfonso et al., 2016). The synthesis of a secondary wall containing lignin aids inside the NOP Receptor/ORL1 Compound reinforcement on the wall and hinders the entry of the pathogen (Miedes et al., 2014). Likewise, the activation of terpenoid and phenylpropanoid produces phytoalexins, which present antimicrobial properties and accumulate in dying cells (Bell et al., 1986). Nonetheless, the expression of phytoalexins in early infection is associated to an incompatible interaction (host resistance) (Bell et al., 1986). At 72 hpi, we observed a clear response from the plant expression for the pathogen switch: genes associated to intracellular signaling and HR are activated. Noteworthy, ERF, putative late blight protein R1-A10 and R1B23, and senescence-specific cysteine protease SAG12 have been expressed, suggesting an induced leaf senescence, triggered by the pathogen to complete the infection cycleFrontiers in Plant Science | frontiersin.orgOctober 2021 | Volume 12 | ArticleBautista et al.Solanum betaceum Response P. betacei(Noh and Amasino, 1999). As infection approached 96 hpi, genes associated to these terms continue their induction with addition to senescence connected terms and jasmonic acid metabolic course of action. The jasmonate and ethylene signal pathways are usually connected together with the response to necrotrophic pathogens (Sun, 2017).AUTHOR CONTRIBUTIONSSR, AB, and NG-P planned and developed the study. NG-P, DBa, and MCB performed the experiments. DBa, DBo, JD, AB, and SR analyzed the information. DBa, JD, MC, and SR wrote the manuscript. All authors contributed to the post and authorized the submitted version.CONCLUSIONIn conclusion, we obtained the first time-series transcriptome of S. betaceum using a comprehensive expression profile across infection brought on by P. betacei. From these data, we observed a close interaction among the host transcriptional response plus the hemibiotrophic infection approach of the pathogen, exhibiting a dynamic defense-related gene response all through the course of infection. We observed different upregulated genes, connected to susceptibility and resistance, that elucidate the continuous response in this compatible interaction: from the recognition of the pathogen and also the activation of defense associated pathways for the final stages of infection with the expression of genes associated with cell death. We hypothesized the nature of this interaction as ETS, with a reprogramming with the host transcription brought on by the pathogen for important resources to help in its colonization. Additional analysis with resistant cultivars might be helpful to know the molecular mechanisms underlying resistance in tree tomato.FUNDINGThis operate was supported by the Division of Biological Sciences at Universidad de los Andes plus the Investigation Fund on the College of Sciences plus the Office of th