O overcome those diverging reaction situations and afford each rotaxanes cateTo overcome these diverging reaction situations and afford each rotaxanes andand catenanes fromsamesame experimental circumstances, a “click” catalyst brew was created nanes from the the experimental conditions, a brand new new “click” catalyst brew was developed up the final the final stoppering and macrocyclization The catalyst catalyst to speed to speed up stoppering and macrocyclization reactions.reactions. Theconsisted consisted of a copper(I)iodide, sodium ascorbate ascorbate (SA), sulfonated bathopheof a mixture ofmixture of copper(I)iodide, sodium (SA), sulfonated bathophenanthroline nanthroline (SBP) and 1,8-diaza-[5.4.0]bicycloundec-7-ane (DBU), all previously dis(SBP) and 1,8-diaza-[5.four.0]bicycloundec-7-ane (DBU), all previously dissolved in a solvent solved inside a solvent of H2 O/EtOH (1:1, H2O/EtOH (1:1, v/v). This extremely active “click” mixture composed mixture composed ofv/v). This extremely active “click” catalyst, when catalyst, a mixture of your mixture on the suitable and SBP-3264 Formula reactant stoichiometry stoichiomadded to when added to a appropriate constructing blocksbuilding blocks and reactantdissolved in etry two Cl2 /CH in a (7:three, v/v) organic solvent mixture, yielded rotaxane 18 rotaxane 18 a CHdissolved 3 CN CH2Cl2/CH3CN (7:3, v/v) organic solvent mixture, yieldedand catenane and respectable 75 and 57 yields, respectively. respectively. Most importantly, such 19 incatenane 19 in respectable 75 and 57 yields, Most importantly, such an innovative an innovative synthetic method permitted the preparation for of first time of interlocked synthetic approach allowed the preparation for the very first time theinterlocked D-A systems D-A systems molecular structural parameters. As a result, the distinct molecular topology with the samewith exactly the same molecular structural parameters. For that reason, the distinct molecular topology rotaxanes and its eventual effects eventual effects in the photoinduced of catenanes and of catenanes and rotaxanes and its within the photoinduced processes on the processes on the interlocked investigated be investigated [886]. interlocked systems could besystems could[886]. A detailed electrochemical, steady-state and time-resolved absorption and emission investigation of rotaxane 18 and catenane 19, too as of quite a few model compounds, wasPhotochem 2021, 1, FOR PEER REVIEWPhotochem 2021,A detailed electrochemical, steady-state and time-resolved absorption and emission investigation of rotaxane 18 and catenane 19, at the same time as of quite a few model compounds, was carried out by Guldi’s group to identify all thermodynamicand kinetic parameters of carried out by Guldi’s group to ascertain all thermodynamic and kinetic parameters on the photoinduced processes (Figure 9). Not surprisingly, the sequence of events following the photoinduced processes (Figure 9). Not surprisingly, the sequence of events Cholesteryl sulfate Endogenous Metabolite followexclusive photoexcitation of theof themoieties in rotaxane 18 and catenane 19 at 420 nm420 ing exclusive photoexcitation ZnP ZnP moieties in rotaxane 18 and catenane 19 at was identical identical to that observed for the ester-linked rotaxanes describedprevious section: nm was to that observed for the ester-linked rotaxanes described inside the in the earlier three (1) EnT around the nson thescale from 1 ZnP to ZnP MLCTMLCT state [Cu(phen)two ] ; (two)]ET section: (1) EnT time ns time scale from 1 the for the 3 state on the in the [Cu(phen)2 ; three MLCT to C to offer the intermediate ZnP Cu(.