Sonello), L.S., F.C., V.L., F.L., C.M.; Information curation, L.S.; Formal analysis, L.S.; Funding acquisition, G.O., S.V., C.R., A.C. (Antonio Cherubini), A.C. (Andrea Corsonello), and F.L.; Investigation, G.O., S.V., C.R., A.C. (Antonio Cherubini), in addition to a.C. (Andrea Corsonello); Methodology, G.O. and F.L.; Supervision, G.O. and F.L.; Writing riginal draft, A.C. (Andrea Corsonello), L.S., V.L., F.L., C.M.; Writing eview and editing, F.C., G.O., S.V., C.R., A.C. (Antonio Cherubini), A.C. (Andrea Corsonello), and F.L. All authors have study and agreed to the published version in the manuscript. Funding: The CRiteria to assess Inappropriate Medication use Perlapine Cancer amongst Elderly complex sufferers (CRIME) project was partially supported by a grant in the Italian Ministry of Health (GR-2007 685638). The present paper was funded by Italian National Analysis Center on Aging (IRCCS INRCA) intramural study funds (Ricerca Corrente).J. Clin. Med. 2021, 10,ten ofInstitutional Review Board Statement: The study was carried out in accordance together with the Declaration of Helsinki, and also the protocol was authorized by the Ethics Committee of the Catholic University of Rome (Project identification code: P/582/CE/2009). Informed Consent Statement: Informed consent was obtained from all subjects involved inside the study. Data Availability Statement: Data are offered for CRIME study researcher at IRCCS INRCA (www.inrca.it (accessed on 8 October 2021)). Acknowledgments: The CRIME study group: Gemelli Hospital, Centro Medicina dell’Invecchiamento, UniversitCattolica del Sacro Cuore, Rome, Italy; University of Perugia; University of Ferrara; Italian National Analysis Center on Aging (IRCCS INRCA) Ancona, Cosenza, Fermo, and Rome. The authors are grateful to Romano Firmani and Moreno Nacciariti for their skillful technical assistance. Conflicts of Interest: The authors declare no conflict of interest. The funders had no role within the design and style of the study; within the collection, analyses, or interpretation of data; within the writing of your manuscript, or inside the choice to publish the results.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access write-up distributed beneath the terms and circumstances of the Creative Commons Attribution (CC BY) license (licenses/by/ 4.0/).In the past decade we’ve got witnessed a important shift towards regional analgesia as the principal strategy in postoperative discomfort management. Single wound infiltration with local anesthetic (WI) or continuous nearby anesthetic infusion via catheters placed into the surgical wound (continuous wound infiltration, CWI) have not too long ago been re-introduced as integral components of multimodal analgesia schemes for postoperative discomfort manage following numerous surgical procedures under common or regional anesthesia [1]. Wound infiltration (WI) with local anesthetics (LA) is utilized because the principal anesthetic for minor surgeries, such asJ. Clin. Med. 2021, 10, 4659. 10.3390/jcmmdpi/journal/jcmJ. Clin. Med. 2021, ten, x FOR PEER REVIEWJ. Clin. Med. 2021, ten,2 of2 ofinfiltration (WI) with neighborhood anesthetics (LA) is applied as the key anesthetic for minor sur geries, like repair of lacerations, skin surgery and remedy of painful oral or genital repair of lacerations, skin surgery and treatment of painful oral or genital lesions, but can lesions, but may also be used as supplement to common anesthesia in a number of Lusutrombopag-d13 Autophagy varieties of sur also beprocedures. CWI improves postoperative analgesia high quality and shows an opioid gical u.