Tudies have reported hypomentalizing AZD3759 web without hypermentalizing in schizophrenia17?0. In another study, hypermentalizing in schizophrenia was entirely explained by lower verbal intelligence and memory, which was not the case for hypomentalizing21. It has also been suggested that hypermentalizing may be related to apophenia, i.e. an increased tendency to perceive connections between unrelated events22. However, only one study reported that patients with delusions of persecution over-attributed contingency, whereas no differences were found with control or non-deluded groups for the attribution of intentions23. The issue of hypo- vs. hyper-mentalizing in schizophrenia thus remains largely open.Laboratoire de Sciences Cognitives et Psycholinguistique, UMR 8554, CNRS-ENS-EHESS, Institut d’ udes de la cognition, Ecole Normale Sup ieure, PSL Research University, 29 Rue d’Ulm, 75005, Paris, France. 2Service Universitaire de Psychiatrie d’adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France. 3Laboratoire HandiRESP EA4047, Universit?Versailles Saint-Quentin-en- Yvelines, 2 Avenue de la Source de la Bi re, 78180 Montigny-le-Bretonneux, France. 4Fondation Fondamental, Cr eil, France. Correspondence and (Z)-4-Hydroxytamoxifen chemical information requests for materials should be addressed to P.R. (email: [email protected])Scientific RepoRts | 6:34728 | DOI: 10.1038/srepwww.nature.com/scientificreports/The other important issue is the distinction between implicit and explicit processing, which Frith and Frith (2008) have convincingly argued is of great relevance to the study of social cognition. Implicit mentalizing involves fast, automatic and relatively inflexible routines while explicit mentalizing rather reflects later, reflexive, decision-making and reporting processes24?7. Social cognitive deficits in patients with schizophrenia might arise at low-level and early perceptual stages. Indeed, a whole section of the literature on schizophrenia is devoted to deficits in basic auditory and visual perceptual processes28,29, including impairments in the visual exploration of static visual scenes30. However, social cognitive deficits in schizophrenia might also arise at higher-level cognitive stages of assessing perceptual evidence. Indeed, in 2004, Frith suggested that social cognition in schizophrenia was characterized by a dissociation between an impaired explicit mentalizing and a spared implicit mentalizing. One major concern in this debate is that the tasks that have been used to assess putatively perceptual abilities or implicit mentalizing, often involve off-line, reflexive and explicit judgments, thereby leaving open several interpretations of patients’ poor performance9. In a closely related area of social cognition, some studies reported preserved implicit perception of facial31,32 and vocal emotions33 in individuals with schizophrenia whereas their explicit recognition was altered. However, to our knowledge, no study has directly compared implicit and explicit mentalizing in the same group of patients with schizophrenia within the same paradigm. Among the various paradigms designed to assess mentalizing in schizophrenia, we chose the Frith-Happ?animations because it has been validated across a number of studies. Because participants are simply asked to report spontaneously what they have seen, this task does not require to solve a problem, as opposed to others classical ToM paradigms. In these animations, two triangles are moving according to rando.Tudies have reported hypomentalizing without hypermentalizing in schizophrenia17?0. In another study, hypermentalizing in schizophrenia was entirely explained by lower verbal intelligence and memory, which was not the case for hypomentalizing21. It has also been suggested that hypermentalizing may be related to apophenia, i.e. an increased tendency to perceive connections between unrelated events22. However, only one study reported that patients with delusions of persecution over-attributed contingency, whereas no differences were found with control or non-deluded groups for the attribution of intentions23. The issue of hypo- vs. hyper-mentalizing in schizophrenia thus remains largely open.Laboratoire de Sciences Cognitives et Psycholinguistique, UMR 8554, CNRS-ENS-EHESS, Institut d’ udes de la cognition, Ecole Normale Sup ieure, PSL Research University, 29 Rue d’Ulm, 75005, Paris, France. 2Service Universitaire de Psychiatrie d’adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France. 3Laboratoire HandiRESP EA4047, Universit?Versailles Saint-Quentin-en- Yvelines, 2 Avenue de la Source de la Bi re, 78180 Montigny-le-Bretonneux, France. 4Fondation Fondamental, Cr eil, France. Correspondence and requests for materials should be addressed to P.R. (email: [email protected])Scientific RepoRts | 6:34728 | DOI: 10.1038/srepwww.nature.com/scientificreports/The other important issue is the distinction between implicit and explicit processing, which Frith and Frith (2008) have convincingly argued is of great relevance to the study of social cognition. Implicit mentalizing involves fast, automatic and relatively inflexible routines while explicit mentalizing rather reflects later, reflexive, decision-making and reporting processes24?7. Social cognitive deficits in patients with schizophrenia might arise at low-level and early perceptual stages. Indeed, a whole section of the literature on schizophrenia is devoted to deficits in basic auditory and visual perceptual processes28,29, including impairments in the visual exploration of static visual scenes30. However, social cognitive deficits in schizophrenia might also arise at higher-level cognitive stages of assessing perceptual evidence. Indeed, in 2004, Frith suggested that social cognition in schizophrenia was characterized by a dissociation between an impaired explicit mentalizing and a spared implicit mentalizing. One major concern in this debate is that the tasks that have been used to assess putatively perceptual abilities or implicit mentalizing, often involve off-line, reflexive and explicit judgments, thereby leaving open several interpretations of patients’ poor performance9. In a closely related area of social cognition, some studies reported preserved implicit perception of facial31,32 and vocal emotions33 in individuals with schizophrenia whereas their explicit recognition was altered. However, to our knowledge, no study has directly compared implicit and explicit mentalizing in the same group of patients with schizophrenia within the same paradigm. Among the various paradigms designed to assess mentalizing in schizophrenia, we chose the Frith-Happ?animations because it has been validated across a number of studies. Because participants are simply asked to report spontaneously what they have seen, this task does not require to solve a problem, as opposed to others classical ToM paradigms. In these animations, two triangles are moving according to rando.